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I.R.F. / Aging news / General / 10022502

Cord Blood Cells Produce Anti-inflammatory Cytokine IL-10 after Transplantation
Posted on: February 25, 2010

It previous studies it has been shown that intravenous administration of human umbilical cord blood (HUCB) mononuclear cells to mice improved blood glucose levels, survival, atherosclerosis and prostate cancer. In this study, scientists examined the effect of HUCB cells on the production of IL-10 levels in IL-10 knockout mice.

It has been proposed that administration of IL-10 may be beneficial in the treatment of inflammatory bowl disease and other diseases which are accompanied by acute inflammation. The results show that mice treated with HUCB cells (108) produce IL-10, as demonstrated by both qualitative and quantitative analyses, and that the levels of this cytokine persisted until the mice were sacrificed (5.5 months after administration).

Immunohistochemical staining of the intestine using HuNu antibody cocktail demonstrated the presence of HUCB cells in the knockout mouse. Although the mice did not receive any immunosuppression, there was no evidence of graft-versus-host disease.

Data suggest that HUCB cells are capable of producing IL-10, and the use of these cells or HUCB may be indicated in the treatment of certain human diseases.

Source: McCarthy BA, Reddi AS, Coakley KM, Nguyen SM, Nayal RR, Javdan M, Paul S, Ende N.; Administration of Human Umbilical Cord Blood Cells Produces Interleukin-10 (IL-10) in IL-10 Deficient Mice without Immunosuppression.; Curr Stem Cell Res Ther. 2009 Dec 2.
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