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I.R.F. / Aging news / General / 07083001

A Third Link Connecting Aging with Double Strand Break Repair
Posted on: August 30, 2007

Until recently, the connection between aging and DNA repair has rested on two classes of observation. First, DNA damage and unrepaired double-strand breaks (DSBs) accumulate with age. Second, several defects in DNA repair genes are associated with early onset of age-related diseases and other signs of premature aging. Now, a third link has emerged.

The mechanisms by which cells repair DSB damage can change dramatically with age, shifting from simpler end-joining processes in younger organisms to homologous mechanisms in which missing genetic information is restored through use of a template. So far this third link between aging and DNA repair has only been observed in a small number of experimental systems, and cannot yet claim the generality of the other two.

Experimental study on this third link could be found in the source article.

Source: Engels WR, Johnson-Schlitz D, Flores C, White L, Preston CR.; A third link connecting aging with double strand break repair.; Cell Cycle. 2007 Jan 15;6(2):131-5. Epub 2007 Jan 28.
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