Innovita Research Foundation

I.R.F. / Aging news / General / 03011501

Nucleolus Protein Involved in Immortality
Posted on: January 15, 2003

A new protein influencing cell cycle has been described in the recent number of Genes and Development*. A protein known as nucleostemin was described here as p53 binding protein localized in the nucleolus and regulating cell differentiation and cycle regulation (cycle exit regulator). This protein is highly expressed in developing cells such as stem cells and tumor one's. The amount of expressed protein decreases with differentiation stage. As more cell is differentiated as minor amounts of nucleostemin are detected. Nucleostemin presence in the tumor cells as uncontrolled cell growth precursor protein could lead to some answers concerning cell's ability of uncontrolled proliferation. Possible interaction of nucleostemin with p53 protein leads to hypotheses of nucleostemin being p53 function regulator (Fig 1).

Fig 1.: nucleostemin, p53 and cell response.

Such promising protein, possible oncogene and found in both stem and tumor cells, could be applied in various fields of biotechnology and medicine after its detail exploration. Talking about stem cell therapy it could be applied as a trigger in stem cells to control their potent proliferation and differentiation.

Source: *Tsai, R.Y.L. & McKay, R.D.G. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev. 16, 2991-3003 (2002).
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